| Product Name | Human C-C chemokine receptor type 6 (CCR6) ELISA Kit |
|---|---|
| Description | Human C-C chemokine receptor type 6 (CCR6) ELISA Kit has high sensitivity and excellent specificity for detection of Human CCR6. No significant cross-reactivity or interference between Human CCR6 and analogues was observed. Chemokine receptor 6 is a CC chemokine receptor. This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids. This Human C-C chemokine receptor type 6 (CCR6) ELISA Kit employs a two-site sandwich ELISA to quantitate CCR6 in samples. An antibody specific for CCR6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyCCR6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CCR6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CCR6 bound in the initial step. The color development is stopped and the intensity of the color is measured. |
| Synonyms | CCR6, BN-1, CD196, CKR-L3, CKR6, CKRL3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, GPRCY4, STRL22, G protein-coupled receptor 29, OTTHUMP00000017618, chemokine (C-C) receptor 6, chemokine receptor-like 3, seven-tra |
| Method | Sandwich ELISA |
| Detection Range | Please inquire |
| Sensitivity | Please inquire |
| Reactivity | Human |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Gene Id | 1235 |
| Storage | 2-8°C |
| Background |
Chemokine receptor 6 is a CC chemokine receptor. This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids. |
| Supplier | Abbkine |
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