Human Carboxyterminal propeptide of type I procollagen (PICP) ELISA Kit
| Product Name | Human Carboxyterminal propeptide of type I procollagen (PICP) ELISA Kit |
|---|---|
| Description | The carboxyterminal propeptide of type I procollagen (PICP) and the aminoterminal propeptide of type I procollagen (PINP) are enzymatically removed from the procollagen molecule by specific proteases. PICP and PINP are indicators of the synthesis of type I collagen. Cleavage of PICP is required for the initiation of fibril formation, whereas PINP may be retained in the collagen molecule resulting in type I pN-collagen. The retention of PINP is transient, unlike the presence of IIIpN-collagen, and has been considered to regulate fibril diameter (Fleischmajer et al. 1985). PICP is a trimeric, globular protein consisting of three polypeptide chains: two pro_1(I) and one pro_2(I) chains. The molecular mass of PICP is 100 000 and it is cleared by mannose receptors in liver endothelial cells (SmedsrÀd et al. 1990). This assay has high sensitivity and excellent specificity for detection of Human PINP. No significant cross-reactivity or interference between Human PINP and analogues was observed. |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.067 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
The carboxyterminal propeptide of type I procollagen (PICP) and the aminoterminal propeptide of type I procollagen (PINP) are enzymatically removed from the procollagen molecule by specific proteases. PICP and PINP are indicators of the synthesis of type I collagen. Cleavage of PICP is required for the initiation of fibril formation, whereas PINP may be retained in the collagen molecule resulting in type I pN-collagen. The retention of PINP is transient, unlike the presence of IIIpN-collagen, and has been considered to regulate fibril diameter (Fleischmajer et al. 1985). PICP is a trimeric, globular protein consisting of three polypeptide chains: two pro_1(I) and one pro_2(I) chains. The molecular mass of PICP is 100 000 and it is cleared by mannose receptors in liver endothelial cells (SmedsrÀd et al. 1990). |
| Supplier | Abebio |
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