| Product Name | Human Epidermal growth factor receptor (EGFR) ELISA Kit |
|---|---|
| Description | The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFRæexists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor _ (TGF_). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. This assay has high sensitivity and excellent specificity for detection of Human EGFR. No significant cross-reactivity or interference between Human EGFR and analogues was observed. |
| Synonyms | ERBB, ERBB1, HER1, PIG61, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|epidermal growth factor recept |
| Method | Sandwich ELISA |
| Detection Range | 3.12-200 ng/mL |
| Sensitivity | 1.22 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFRæexists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor _ (TGF_). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. |
| Supplier | Abebio |
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