| Product Name | Human Epididymal-specific lipocalin-6 (LCN6) ELISA Kit |
|---|---|
| Description | Using database analysis and cDNA sequencing from a human caput library, Hamil et al. (2003) identified LCN6. The 163-amino acid LCN6 protein contains a predicted 20-amino acid signal peptide.human LCN6 is 93% identical to rhesus monkey Lcn6 and lacks a second, C-terminal cysteine found in many lipocalins. The LCN6 protein contains multiple phosphorylation sites, and structural prediction programs showed that LCN6 displays the characteristic lipocalin 3-dimensional structure. Northern blot analysis revealed robust expression of a 1-kb LCN6 transcript in epididymis. Using immunohistochemistry, strong expression of LCN6 protein in the caput epithelium and lumen; immunofluorescence of human spermatozoa showed strong LCN6 expression in large patches in the postacrosomal region of the head. This assay has high sensitivity and excellent specificity for detection of Human LCN6. No significant cross-reactivity or interference between Human LCN6 and analogues was observed. |
| Synonyms | RP11-216L13.2, LCN5, UNQ643, hLcn5, epididymal-specific lipocalin LCN6|lipocalin 5 |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.137 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Using database analysis and cDNA sequencing from a human caput library, Hamil et al. (2003) identified LCN6. The 163-amino acid LCN6 protein contains a predicted 20-amino acid signal peptide.human LCN6 is 93% identical to rhesus monkey Lcn6 and lacks a second, C-terminal cysteine found in many lipocalins. The LCN6 protein contains multiple phosphorylation sites, and structural prediction programs showed that LCN6 displays the characteristic lipocalin 3-dimensional structure. Northern blot analysis revealed robust expression of a 1-kb LCN6 transcript in epididymis. Using immunohistochemistry, strong expression of LCN6 protein in the caput epithelium and lumen; immunofluorescence of human spermatozoa showed strong LCN6 expression in large patches in the postacrosomal region of the head. |
| Supplier | Abebio |
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