| Product Name | Human Excitatory amino acid transporter 2 (SLC1A2) ELISA Kit |
|---|---|
| Description | SLC1A2 / EAAT2 is a member of a family of the solute carrier family of proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Ceftriaxone, an antibiotic, has been shown to induce/enhance the expression of EAAT2, resulting in reduced glutamate activity. Ceftriaxone has been shown to reduce the development and expression of tolerance to opiates and other drugs of abuse. EAAT2 may possess an important role in modulating drug addiction and tolerance. This assay has high sensitivity and excellent specificity for detection of Human SLC1A2. No significant cross-reactivity or interference between Human SLC1A2 and analogues was observed. |
| Synonyms | EAAT2, GLT-1, excitatory amino acid transporter 2|excitotoxic amino acid transporter 2|glial high affinity glutamate transporter|glutamate/aspartate transporter II|sodium-dependent glutamate/asparta |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.117 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
SLC1A2 / EAAT2 is a member of a family of the solute carrier family of proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Ceftriaxone, an antibiotic, has been shown to induce/enhance the expression of EAAT2, resulting in reduced glutamate activity. Ceftriaxone has been shown to reduce the development and expression of tolerance to opiates and other drugs of abuse. EAAT2 may possess an important role in modulating drug addiction and tolerance. |
| Supplier | Abebio |
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