| Product Name | Human Kallikrein-13 (KLK13) ELISA Kit |
|---|---|
| Description | Kallikrein-13 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. in a 300-kb region on chromosome 19q13.3-q13.4, where other kallikrein genes are localized. KLK13 exists in 2 main forms: a long form that encodes a deduced 277-amino acid protein with a predicted molecular mass of 30.6 kD, and a short form, referred to as the short KLKL4 variant, that uses an upstream alternative splice donor site located in exon 3 that generates a truncated protein. The KLK13 protein shares 51% amino acid identity with KLK11 and KLK6. This assay has high sensitivity and excellent specificity for detection of Human KLK13. No significant cross-reactivity or interference between Human KLK13 and analogues was observed. |
| Synonyms | DKFZp586J1923, KLK-L4, KLKL4, kallikrein 13|kallikrein-like gene 4 |
| Method | Sandwich ELISA |
| Detection Range | 31.25-2000 pg/mL |
| Sensitivity | 12.6 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Kallikrein-13 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. in a 300-kb region on chromosome 19q13.3-q13.4, where other kallikrein genes are localized. KLK13 exists in 2 main forms: a long form that encodes a deduced 277-amino acid protein with a predicted molecular mass of 30.6 kD, and a short form, referred to as the short KLKL4 variant, that uses an upstream alternative splice donor site located in exon 3 that generates a truncated protein. The KLK13 protein shares 51% amino acid identity with KLK11 and KLK6. |
| Supplier | Abebio |
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