| Product Name | Human Keratin, type II cytoskeletal 4 (KRT4) ELISA Kit |
|---|---|
| Description | Keratin 4 isa member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq]. Sequence Note: The RefSeq represents one of two co-dominant alleles identified for this gene. This assay has high sensitivity and excellent specificity for detection of Human KRT4. No significant cross-reactivity or interference between Human KRT4 and analogues was observed. |
| Synonyms | CK4, CYK4, FLJ31692, K4, cytokeratin 4|keratin, type II cytoskeletal 4 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.057 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Keratin 4 isa member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq]. Sequence Note: The RefSeq represents one of two co-dominant alleles identified for this gene. |
| Supplier | Abebio |
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