Human Mannma binding protein/mannan binding lectin (MBP/MBL) ELISA Kit
| Product Name | Human Mannma binding protein/mannan binding lectin (MBP/MBL) ELISA Kit |
|---|---|
| Description | Mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism.It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2 -dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. This assay has high sensitivity and excellent specificity for detection of Human MBL2. No significant cross-reactivity or interference between Human MBL2 and analogues was observed. |
| Synonyms | COLEC1, HSMBPC, MBL, MBP, MBP1, MGC116832, MGC116833, mannan-binding lectin|mannose-binding lectin 2, soluble (opsonic defect)|mannose-binding protein C|soluble mannose-binding lectin |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.061 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism.It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2 -dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. |
| Supplier | Abebio |
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