Human MAP kinase-activating death domain protein (MADD) ELISA Kit
| Product Name | Human MAP kinase-activating death domain protein (MADD) ELISA Kit |
|---|---|
| Description | Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. This protein is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. This assay has high sensitivity and excellent specificity for detection of Human MADD. No significant cross-reactivity or interference between Human MADD and analogues was observed. |
| Synonyms | DENN, FLJ35600, FLJ36300, IG20, KIAA0358, RAB3GEP, MAP-kinase activating death domain-containing protein|OTTHUMP00000197132|OTTHUMP00000197133|OTTHUMP00000197138|OTTHUMP00000197139|Rab3 GDP/GTP exch |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | 7.8 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. This protein is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. |
| Supplier | Abebio |
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