Human MARVEL domain-containing protein 2 (MARVELD2) ELISA Kit
| Product Name | Human MARVEL domain-containing protein 2 (MARVELD2) ELISA Kit |
|---|---|
| Description | MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts.The 555-amino acid protein contains cytoplasmic N and C termini, 2 transmembrane domains, and 2 extracellular loops. Northern blot analysis detected high expression of Tric in epithelium-derived tissues, including small intestine, kidney, and lung. Western blot analysis of mouse epithelial cell lines revealed an approximately 66-kD protein, as well as larger phosphorylated intracellular forms. Immunofluorescence microscopy showed expression of Tric predominantly at tricellular contacts where occludin (OCLN)-positive bicellular TJs converged. Tric-positive structures appeared as short rods through confocal microscopy. This assay has high sensitivity and excellent specificity for detection of Human MARVELD2. No significant cross-reactivity or interference between Human MARVELD2 and analogues was observed. |
| Synonyms | DFNB49, FLJ30532, MARVD2, MRVLDC2, Tric, MARVEL (membrane-associating) domain containing 2|tricellulin |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.125 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts.The 555-amino acid protein contains cytoplasmic N and C termini, 2 transmembrane domains, and 2 extracellular loops. Northern blot analysis detected high expression of Tric in epithelium-derived tissues, including small intestine, kidney, and lung. Western blot analysis of mouse epithelial cell lines revealed an approximately 66-kD protein, as well as larger phosphorylated intracellular forms. Immunofluorescence microscopy showed expression of Tric predominantly at tricellular contacts where occludin (OCLN)-positive bicellular TJs converged. Tric-positive structures appeared as short rods through confocal microscopy. |
| Supplier | Abebio |
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