| Product Name | Human Melanocortin receptor 5 (MC5R) ELISA Kit |
|---|---|
| Description | Melanocortin receptor 5 is located on the chromosome 18 in the human genome. when the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum. Melanocortin-1 receptor (MC1R) is found in melanocytes and appears to be the alpha-melanocyte stimulating hormone (MSH) receptor. MC2R is localized to adrenocortical cells and is thus thought to be the ACTH receptor. MC3R and MC4R are localized primarily to sites in the brain. Each receptor has a unique pattern of affinity for the various melanocortin ligands. Gantz et al. (1994) reported the molecular cloning of a novel gene encoding a fifth member of the MCR family in the mouse. Chowdhary et al. (1995) mapped the human MC5R gene to 18p11.2 by fluorescence in situ hybridization. This assay has high sensitivity and excellent specificity for detection of Human MC5R. No significant cross-reactivity or interference between Human MC5R and analogues was observed. |
| Synonyms | Melanocortin receptor 5 |
| Method | Sandwich ELISA |
| Detection Range | 0.78-50 ng/mL |
| Sensitivity | 0.25 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Melanocortin receptor 5 is located on the chromosome 18 in the human genome. when the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum. Melanocortin-1 receptor (MC1R) is found in melanocytes and appears to be the alpha-melanocyte stimulating hormone (MSH) receptor. MC2R is localized to adrenocortical cells and is thus thought to be the ACTH receptor. MC3R and MC4R are localized primarily to sites in the brain. Each receptor has a unique pattern of affinity for the various melanocortin ligands. Gantz et al. (1994) reported the molecular cloning of a novel gene encoding a fifth member of the MCR family in the mouse. Chowdhary et al. (1995) mapped the human MC5R gene to 18p11.2 by fluorescence in situ hybridization. |
| Supplier | Abebio |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
