Human Mothers against decapentaplegic homolog 5 (SMAD5) ELISA Kit
| Product Name | Human Mothers against decapentaplegic homolog 5 (SMAD5) ELISA Kit |
|---|---|
| Description | SMAD5 or Mothers against decapentaplegic homolog 5 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF_ superfamily of modulators. Like many other TGF_ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGF_ is an inhibitor of hematopoietic progenitor cells. This assay has high sensitivity and excellent specificity for detection of Human SMAD5. No significant cross-reactivity or interference between Human SMAD5 and analogues was observed. |
| Synonyms | DKFZp781C1895, DKFZp781O1323, Dwfc, JV5-1, MADH5, MAD homolog 5|MAD, mothers against decapentaplegic homolog 5|SMA- and MAD-related protein 5|SMAD, mothers against DPP homolog 5|mothers against deca |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.123 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
SMAD5 or Mothers against decapentaplegic homolog 5 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF_ superfamily of modulators. Like many other TGF_ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGF_ is an inhibitor of hematopoietic progenitor cells. |
| Supplier | Abebio |
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