Human Mothers against decapentaplegic homolog 9 (SMAD9) ELISA Kit
| Product Name | Human Mothers against decapentaplegic homolog 9 (SMAD9) ELISA Kit |
|---|---|
| Description | SMAD9 or Mothers against decapentaplegic homolog 9 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF_ superfamily of modulators. Like many other TGF_ family members, SMAD9 is involved in cell signalling. When a bone morphogenetic protein binds to a receptor (BMP type 1 receptor kinase) it causes SMAD9 to interact with SMAD anchor for receptor activation (SARA).The binding of ligands causes the phosphorylation of the SMAD9 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. This assay has high sensitivity and excellent specificity for detection of Human SMAD9. No significant cross-reactivity or interference between Human SMAD9 and analogues was observed. |
| Synonyms | MADH6, MADH9, SMAD8, SMAD8A, SMAD8B, MAD (mothers against decapentaplegic, Drosophila) homolog 9|MAD, mothers against decapentaplegic homolog 9|Mothers against decapentaplegic, drosophila, homolog o |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.061 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
SMAD9 or Mothers against decapentaplegic homolog 9 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF_ superfamily of modulators. Like many other TGF_ family members, SMAD9 is involved in cell signalling. When a bone morphogenetic protein binds to a receptor (BMP type 1 receptor kinase) it causes SMAD9 to interact with SMAD anchor for receptor activation (SARA).The binding of ligands causes the phosphorylation of the SMAD9 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor |
| Supplier | Abebio |
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