Human Mucosal addressin cell adhesion molecule-1 (MADCAM-1) ELISA Kit
| Product Name | Human Mucosal addressin cell adhesion molecule-1 (MADCAM-1) ELISA Kit |
|---|---|
| Description | Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes.The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. The carry carbohydrates in order to be recognized by L-selectin. The predicted amino acid sequence defines the mucosal addressin as a novel immunoglobulin family member with 2 N-terminal domains that display strong homology to previously described vascular adhesion receptors for leukocytes: ICAM1 and VCAM1. The membrane proximal domain is homologous to the third domain of another mucosa-associated member of the immunoglobulin family, namely, IgA1 . This assay has high sensitivity and excellent specificity for detection of Human MADCAM1. No significant cross-reactivity or interference between Human MADCAM1 and analogues was observed. |
| Synonyms | MACAM1, mucosal addressin cell adhesion molecule-1 |
| Method | Sandwich ELISA |
| Detection Range | 78.1-5000 pg/mL |
| Sensitivity | 37 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes.The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. The carry carbohydrates in order to be recognized by L-selectin. The predicted amino acid sequence defines the mucosal addressin as a novel immunoglobulin family member with 2 N-terminal domains that display strong homology to previously described vascular adhesion receptors for leukocytes: ICAM1 and VCAM1. The membrane proximal domain is homologous to the third domain of another mucosa-associated member of the immunoglobulin family, namely, IgA1 . |
| Supplier | Abebio |
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