| Product Name | Human Neuroendocrine protein 7B2 (SCG5) ELISA Kit |
|---|---|
| Description | Neuroendocrine protein 7B2 is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 and is required for the production of an active PC2 enzyme. Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. This assay has high sensitivity and excellent specificity for detection of Human SCG5. No significant cross-reactivity or interference between Human SCG5 and analogues was observed. |
| Synonyms | 7B2, P7B2, SGNE1, SgV, prohormone convertase chaperone|secretogranin V|secretory granule, neuroendocrine protein 1 (7B2 protein) |
| Method | Sandwich ELISA |
| Detection Range | 7.81-500 pg/mL |
| Sensitivity | 3.5 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Neuroendocrine protein 7B2 is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 and is required for the production of an active PC2 enzyme. Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. |
| Supplier | Abebio |
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