| Product Name | Human Neuroserpin (SERPINI1) ELISA Kit |
|---|---|
| Description | Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. It is a member of the serpin superfamily of serine proteinase inhibitors. Neuroserpin is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. This assay has high sensitivity and excellent specificity for detection of Human SERPINI1. No significant cross-reactivity or interference between Human SERPINI1 and analogues was observed. |
| Synonyms | DKFZp781N13156, PI12, neuroserpin, neuroserpin|serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 |
| Method | Sandwich ELISA |
| Detection Range | 0.781-50 ng/mL |
| Sensitivity | 0.34 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. It is a member of the serpin superfamily of serine proteinase inhibitors. Neuroserpin is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| Supplier | Abebio |
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