Human Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor epsilon (NFKBIE) ELISA Kit
| Product Name | Human Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor epsilon (NFKBIE) ELISA Kit |
|---|---|
| Description | NFKBIE protein expression is up-regulated following NF-_B activation and during myelopoiesis. NFKBIE is able to inhibit NF-_B-directed transactivation via cytoplasmic retention of REL proteins.NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-_B transcription factor complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex.For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1). This assay has high sensitivity and excellent specificity for detection of Human NFKBIE. No significant cross-reactivity or interference between Human NFKBIE and analogues was observed. |
| Synonyms | IKBE, |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | NFKBIE protein expression is up-regulated following NF-_B activation and during myelopoiesis. NFKBIE is able to inhibit NF-_B-directed transactivation via cytoplasmic retention of REL proteins.NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-_B transcription factor complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex.For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1). |
| Supplier | Abebio |
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