| Product Name | Human Piwi-like protein 1 (PIWIL1) ELISA Kit |
|---|---|
| Description | PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Miwi associated with both piRNAs and mRNAs in cytosolic ribonucleoprotein and polysome fractions of mouse testicular extract. As polysomes increased in early spermiogenesis, Miwi levels increased in polysome fractions. Moreover, Miwi associated with the mRNA cap-binding complex. This assay has high sensitivity and excellent specificity for detection of Human PIWIL1. No significant cross-reactivity or interference between Human PIWIL1 and analogues was observed. |
| Synonyms | HIWI, MIWI, PIWI, piwi homolog|piwi-like 1 |
| Method | Sandwich ELISA |
| Detection Range | 0.5-20 ng/mL |
| Sensitivity | 0.2 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Miwi associated with both piRNAs and mRNAs in cytosolic ribonucleoprotein and polysome fractions of mouse testicular extract. As polysomes increased in early spermiogenesis, Miwi levels increased in polysome fractions. Moreover, Miwi associated with the mRNA cap-binding complex. |
| Supplier | Abebio |
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