| Product Name | Human Prefoldin subunit 1 (PFDN1) ELISA Kit |
|---|---|
| Description | Prefoldin subunit 1 is a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. By analysis of the protein by reverse-phase HPLC, they identified 6 prefoldin polypeptides. By sequence analysis, they identified the corresponding mammalian cDNA sequences, of which 4 were human. These 4 included PFDN1, which encodes a 122-amino acid protein. PFDN3 is identical to VBP1, whereas PFDN4 and PFDN5encode a possible transcription factor and a c-myc binding protein, respectively. This assay has high sensitivity and excellent specificity for detection of Human PFDN1. No significant cross-reactivity or interference between Human PFDN1 and analogues was observed. |
| Synonyms | PDF, PFD1, prefoldin 1 |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.112 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Prefoldin subunit 1 is a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. By analysis of the protein by reverse-phase HPLC, they identified 6 prefoldin polypeptides. By sequence analysis, they identified the corresponding mammalian cDNA sequences, of which 4 were human. These 4 included PFDN1, which encodes a 122-amino acid protein. PFDN3 is identical to VBP1, whereas PFDN4 and PFDN5encode a possible transcription factor and a c-myc binding protein, respectively. |
| Supplier | Abebio |
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