| Product Name | Human Prenylcysteine oxidase 1 (PCYOX1) ELISA Kit |
|---|---|
| Description | Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product . The deduced 505-amino acid protein contains a predicted signal sequence, several transmembrane regions, and potential N-glycosylation sites. Northern blot analysis detected a 6-kb transcript in heart, kidney, liver, colon, placenta, skeletal muscle, and pancreas, with low expression in brain and no expression in spleen. The 3-prime untranslated region contains several SINEs, including Alu and MIR sequences. The predicted protein has 506 amino acids. RT-PCR ELISA detected high to moderate expression in all adult and fetal human tissues and all specific brain regions tested. This assay has high sensitivity and excellent specificity for detection of Human PCYOX1. No significant cross-reactivity or interference between Human PCYOX1 and analogues was observed. |
| Synonyms | KIAA0908, PCL1, prenylcysteine lyase |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.118 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product . The deduced 505-amino acid protein contains a predicted signal sequence, several transmembrane regions, and potential N-glycosylation sites. Northern blot analysis detected a 6-kb transcript in heart, kidney, liver, colon, placenta, skeletal muscle, and pancreas, with low expression in brain and no expression in spleen. The 3-prime untranslated region contains several SINEs, including Alu and MIR sequences. The predicted protein has 506 amino acids. RT-PCR ELISA detected high to moderate expression in all adult and fetal human tissues and all specific brain regions tested. |
| Supplier | Abebio |
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