Human Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) ELISA Kit
| Product Name | Human Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) ELISA Kit |
|---|---|
| Description | PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1) through recruitment of protein phosphatase-1 (PP1) catalytic subunits. Ppp1r15b -/- mice showed low hematocrit and red blood cell count, with qualitative abnormalities in red cell size and shape. Histologic examination of mutant liver was consistent with compensatory proliferation of blood precursors. Ppp1r15b -/- mouse embryo fibroblasts showed elevated Eif2-alpha phosphorylation. Ppp1r15b -/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -/- embryos with wildtype Eif2-alpha. This assay has high sensitivity and excellent specificity for detection of Human PPP1R15B. No significant cross-reactivity or interference between Human PPP1R15B and analogues was observed. |
| Synonyms | FLJ14744, protein phosphatase 1, regulatory subunit 15B |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.118 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1) through recruitment of protein phosphatase-1 (PP1) catalytic subunits. Ppp1r15b -/- mice showed low hematocrit and red blood cell count, with qualitative abnormalities in red cell size and shape. Histologic examination of mutant liver was consistent with compensatory proliferation of blood precursors. Ppp1r15b -/- mouse embryo fibroblasts showed elevated Eif2-alpha phosphorylation. Ppp1r15b -/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -/- embryos with wildtype Eif2-alpha. |
| Supplier | Abebio |
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