Human Pulmonary surfactant-associated protein B (SP-B) ELISA Kit
| Product Name | Human Pulmonary surfactant-associated protein B (SP-B) ELISA Kit |
|---|---|
| Description | SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure. The SFTPB is an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. This assay has high sensitivity and excellent specificity for detection of Human SFTPB. No significant cross-reactivity or interference between Human SFTPB and analogues was observed. |
| Synonyms | PSP-B, SFTB3, SFTP3, SMDP1, SP-B, OTTHUMP00000203253|Pulmonary surfactant-associated protein B, 18kD|surfactant, pulmonary-associated protein B |
| Method | Sandwich ELISA |
| Detection Range | 1.56-100 ng/mL |
| Sensitivity | 0.61 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure. The SFTPB is an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. |
| Supplier | Abebio |
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