| Product Name | Human Putative peptide YY-3 (PYY3) ELISA Kit |
|---|---|
| Description | Peptide YY(3-36) , a Y2R agonist, is released from the gastrointestinal tract postprandially in proportion to the calorie content of a meal. PYY(3-36) also inhibits food intake in mice but not in Y2r-null mice, which suggests that the anorectic effect requires the Y2R. Peripheral administration of PYY(3-36) increases c-Fos immunoreactivity in the arcuate nucleus and decreases hypothalamic Npy messenger RNA. Intra-arcuate injection of PYY(3-36) inhibits food intake. PYY(3-36) also inhibits electrical activity of NPY nerve terminals, thus activating adjacent pro-opiomelanocortin (POMC) neurons. In humans, infusion of normal postprandial concentrations of PYY(3-36) significantly decreases appetite and reduces food intake by 33% over 24 h. Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway. This assay has high sensitivity and excellent specificity for detection of Human PYY3. No significant cross-reactivity or interference between Human PYY3 and analogues was observed. |
| Synonyms | RP13-377G1_A.2, |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 pg/mL_ |
| Sensitivity | 0.078 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Peptide YY(3-36) , a Y2R agonist, is released from the gastrointestinal tract postprandially in proportion to the calorie content of a meal. PYY(3-36) also inhibits food intake in mice but not in Y2r-null mice, which suggests that the anorectic effect requires the Y2R. Peripheral administration of PYY(3-36) increases c-Fos immunoreactivity in the arcuate nucleus and decreases hypothalamic Npy messenger RNA. Intra-arcuate injection of PYY(3-36) inhibits food intake. PYY(3-36) also inhibits electrical activity of NPY nerve terminals, thus activating adjacent pro-opiomelanocortin (POMC) neurons. In humans, infusion of normal postprandial concentrations of PYY(3-36) significantly decreases appetite and reduces food intake by 33% over 24 h. Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway. |
| Supplier | Abebio |
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