| Product Name | Human Ras-related protein Rab-5C (RAB5C) ELISA Kit |
|---|---|
| Description | Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment. Han et al. (1996) isolated fetal lung cDNAs encoding a RAB protein that they designated RABL (RAB5-like). The predicted 216-amino acid RABL protein shares 86% identity with RAB5A and RAB5B and contains the conserved GTP-binding site characteristic of RAS proteins. RT-PCR analysis revealed that RABL is expressed ubiquitously. By analysis of cloned segments, Albertsen et al. (1994) determined that the RABL gene, which they called BC1-16, is located in the BRCA1 gene region on chromosome 17q12-q21. Han et al. (1996) refined the map position to 17q21.2 using FISH. This assay has high sensitivity and excellent specificity for detection of Human RAB5C. No significant cross-reactivity or interference between Human RAB5C and analogues was observed. |
| Synonyms | MGC117217, MGC138857, RAB5CL, RABL, RAB, member of RAS oncogene family-like|RAB5C, member of RAS oncogene family |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.055 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment. Han et al. (1996) isolated fetal lung cDNAs encoding a RAB protein that they designated RABL (RAB5-like). The predicted 216-amino acid RABL protein shares 86% identity with RAB5A and RAB5B and contains the conserved GTP-binding site characteristic of RAS proteins. RT-PCR analysis revealed that RABL is expressed ubiquitously. By analysis of cloned segments, Albertsen et al. (1994) determined that the RABL gene, which they called BC1-16, is located in the BRCA1 gene region on chromosome 17q12-q21. Han et al. (1996) refined the map position to 17q21.2 using FISH. |
| Supplier | Abebio |
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