Human Retinoic acid receptor responder protein 2 (RARRES2) ELISA Kit
| Product Name | Human Retinoic acid receptor responder protein 2 (RARRES2) ELISA Kit |
|---|---|
| Description | Chemerin is a novel protein identified as the natural ligand of ChemR23 (chemerinR), a previously orphan G protein-coupled receptor expressed in immature dendritic cells and macrophages. It is a member of the Cystatin superfamily. Chemerin is synthesized as a 163 aa secreted precursor, prochemerin, which contains a hydrophobic 20 aa N-terminal sequence, an intervening 137 aa Cystatin fold-containing domain, and a six aa C-terminal prosegment. It is activated by proteases of the coagulation, fibrinolytic, and inflammatory cascades and converted into a full agonist of chemerinR by proteolytic removal of the last six amino acids.Chemerin is a chemoattractant for cells bearing the Chem R23 receptor, including plasmacytoid dendritic cells and tissue macrophages. This assay has high sensitivity and excellent specificity for detection of Human RARRES2. No significant cross-reactivity or interference between Human RARRES2 and analogues was observed. |
| Synonyms | HP10433, TIG2, chemerin |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.069 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Chemerin is a novel protein identified as the natural ligand of ChemR23 (chemerinR), a previously orphan G protein-coupled receptor expressed in immature dendritic cells and macrophages. It is a member of the Cystatin superfamily. Chemerin is synthesized as a 163 aa secreted precursor, prochemerin, which contains a hydrophobic 20 aa N-terminal sequence, an intervening 137 aa Cystatin fold-containing domain, and a six aa C-terminal prosegment. It is activated by proteases of the coagulation, fibrinolytic, and inflammatory cascades and converted into a full agonist of chemerinR by proteolytic removal of the last six amino acids.Chemerin is a chemoattractant for cells bearing the Chem R23 receptor, including plasmacytoid dendritic cells and tissue macrophages. |
| Supplier | Abebio |
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