| Product Name | Human Ribonuclease P protein subunit p29 (POP4) ELISA Kit |
|---|---|
| Description | POP4 encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants.The deduced 220-amino acid basic protein is rich in arginine and lysine, has nuclear localization sequences, and has a predicted molecular mass of approximately 25 kD. RPP29 is 23% identical to the yeast Pop4 protein. Fluorescent microscopy demonstrated nuclear and nucleolar expression of RPP29. Immunoblot analysis showed that antibodies to RPP14 or RPP29 precipitate native RNase P. This assay has high sensitivity and excellent specificity for detection of Human POP4. No significant cross-reactivity or interference between Human POP4 and analogues was observed. |
| Synonyms | RPP29, processing of precursor 4|ribonuclease P protein subunit p29 |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | POP4 encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants.The deduced 220-amino acid basic protein is rich in arginine and lysine, has nuclear localization sequences, and has a predicted molecular mass of approximately 25 kD. RPP29 is 23% identical to the yeast Pop4 protein. Fluorescent microscopy demonstrated nuclear and nucleolar expression of RPP29. Immunoblot analysis showed that antibodies to RPP14 or RPP29 precipitate native RNase P. |
| Supplier | Abebio |
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