| Product Name | Human Semaphorin-3C (SEMA3C) ELISA Kit |
|---|---|
| Description | The 616-amino acid human semaphorin E contains an N-terminal signal sequence of 15 amino acids that is followed by a semaphorin domain. In vitro translation of the semaphorin E cDNA yielded a 70-kD protein. The authors showed that semaphorin E is secreted by mammalian cells. By Northern blot analysis, semaphorin E was expressed as a 5.2-kb transcript in all human tissues tested. CDDP-sensitive cells transfected with semaphorin E cDNA acquired CDDP-resistance. Semaphorin E was overexpressed in CDDP-resistant cell lines and was induced by diverse chemotherapeutic drugs and by x-ray and UV irradiation. Aberrant semaphorin E protein expression was detected immunohistochemically. This assay has high sensitivity and excellent specificity for detection of Human SEMA3C. No significant cross-reactivity or interference between Human SEMA3C and analogues was observed. |
| Synonyms | SEMAE, SemE, OTTHUMP00000207932|semaphorin 3C|semaphorin E |
| Method | Sandwich ELISA |
| Detection Range | 15.6-1000 pg/mL |
| Sensitivity | 6.8 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
The 616-amino acid human semaphorin E contains an N-terminal signal sequence of 15 amino acids that is followed by a semaphorin domain. In vitro translation of the semaphorin E cDNA yielded a 70-kD protein. The authors showed that semaphorin E is secreted by mammalian cells. By Northern blot analysis, semaphorin E was expressed as a 5.2-kb transcript in all human tissues tested. CDDP-sensitive cells transfected with semaphorin E cDNA acquired CDDP-resistance. Semaphorin E was overexpressed in CDDP-resistant cell lines and was induced by diverse chemotherapeutic drugs and by x-ray and UV irradiation. Aberrant semaphorin E protein expression was detected immunohistochemically |
| Supplier | Abebio |
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