| Product Name | Human Soluble CD163 (sCD163) ELISA Kit |
|---|---|
| Description | CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages.Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin c by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.CD163 may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. It exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. This assay has high sensitivity and excellent specificity for detection of Human CD163. No significant cross-reactivity or interference between Human CD163 and analogues was observed. |
| Synonyms | M130, MM130, CD163 antigen|macrophage-associated antigen |
| Method | Sandwich ELISA |
| Detection Range | 0.625-40 ng/mL |
| Sensitivity | 0.273 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages.Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin c by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.CD163 may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. It exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. |
| Supplier | Abebio |
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