Human Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) ELISA Kit
| Product Name | Human Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) ELISA Kit |
|---|---|
| Description | This protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. This assay has high sensitivity and excellent specificity for detection of Human TNFSF12. No significant cross-reactivity or interference between Human TNFSF12 and analogues was observed. |
| Synonyms | APO3L, DR3LG, MGC129581, MGC20669, TWEAK, APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | This protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. |
| Supplier | Abebio |
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