| Product Name | Human Sphingomyelin phosphodiesterase 2 (SMPD2) ELISA Kit |
|---|---|
| Description | SMPD2 isa protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. Neutral sphingomyelinase (N-SMase) activity was first described in fibroblasts from patients with Niemann-Pick disease _ a lysosomal storage disease characterized by deficiencies in acid SMase . Subsequent study found that this enzyme was the product of a distinct gene, had an optimum pH of 7.4, was dependent on Mg2+ ions for activity, and was particularly enriched in brain . This assay has high sensitivity and excellent specificity for detection of Human SMPD2. No significant cross-reactivity or interference between Human SMPD2 and analogues was observed. |
| Synonyms | RP5-919F19.2, ISC1, NSMASE, NSMASE1, sphingomyelin phosphodiesterase 2, neutral |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.067 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
SMPD2 isa protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. Neutral sphingomyelinase (N-SMase) activity was first described in fibroblasts from patients with Niemann-Pick disease _ a lysosomal storage disease characterized by deficiencies in acid SMase . Subsequent study found that this enzyme was the product of a distinct gene, had an optimum pH of 7.4, was dependent on Mg2+ ions for activity, and was particularly enriched in brain . |
| Supplier | Abebio |
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