| Product Name | Recombinant Human Dystonin (DST), partial |
|---|---|
| Description | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus.By similarity3 Publications Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Synonyms |
230 kDa bullous pemphigoid antigen 230/240 kDa bullous pemphigoid antigen Bullous pemphigoid antigen 1 Short name:BPA Short name:Bullous pemphigoid antigen |
| Host | E.coli |
| Molecular Weight | 39.1 |
| Amino Acid Sequence | MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSG |
| Protein Length | Partial of Isoform 3, 1-195aa |
| Tag | N-terminal 6xHis-SUMO-tagged |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Tris-based buffer, 50% glycerol |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| References | "Cloning and characterization of the neural isoforms of human dystonin."Brown A., Dalpe G., Mathieu M., Kothary R.Genomics 29:777-780(1995) |
| Background |
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus.By similarity3 Publications Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Supplier | Cusabio |
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