Recombinant Human SUMO-conjugating enzyme UBC9 (UBE2I), partial
| Product Name | Recombinant Human SUMO-conjugating enzyme UBC9 (UBE2I), partial |
|---|---|
| Description | Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386' |
| Synonyms | SUMO-protein ligaseUbiquitin carrier protein 9Ubiquitin carrier protein IUbiquitin-conjugating enzyme E2 IUbiquitin-protein ligase Ip18 |
| Host | E.coli |
| Molecular Weight | 44.9 |
| Amino Acid Sequence | MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAP |
| Protein Length | Partial, 1-157aa |
| Tag | N-terminal GST-tagged |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Tris-based buffer, 50% glycerol |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| References | Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9.Yasugi T., Howley P.M.Nucleic Acids Res. 24:2005-2010(1996) |
| Background | Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386' |
| Supplier | Cusabio |
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