| Product Name | Synstatin |
|---|---|
| Description |
Synstatin is a peptide derived from amino acids 92-119 of the mouse syndecan sequence and is the active site for the αvβ3 and αvβ5 integrin activation mechanism. Syndecan is a critical regulator of these two integrins during angiogenesis and tumourigenesis, and this activation process can be blocked by the synstatin peptide. Synstatin displays an IC50 of 100-300 nM when used in vitro to inhibit αvβ3 dependent adhesion and cell migration on vitronectin or in aortic ring angiogenesis assays. Synstatin is a potent inhibitor of angiogenesis in vivo and blocks αvβ3 mediated tumour cell adhesion and migration and tumour formation in mouse models.
|
| Synonyms | SSTN, SSTN92-119 |
| Molecular Weight | 3032.31 Da |
| Target | Protein-protein interactions,Integrin receptors |
| Amino Acid Sequence | LPAGEKPEEGEPVLHVEAEPGFTARDKE |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Beauvais et al (2009) Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med. 206(3) 691 PMID: 19255147Rapraeger (2013) Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. 280(10) 2207 PMID: 23375101 Related areasAll peptides >All integrin receptor modulators >All protein-protein modulators >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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