| Product Name | T100-Mut |
|---|---|
| Description | T100-Mut is a cell permeable peptide which enhances the association of TRPA1 and TRPV1 and strongly inhibits TRPA1 associated pain. The design of T100-Mut originated from Tmem100, a 134-amino acid protein found in dorsal root ganglia (DRG), co-expressed with TRPA1 and TRPV1 with which it forms a complex. Tmem100 decreases the interaction between TRPA1 and TRPV1, whereas a Tmem100 mutant, Tmem100-3Q, exerts the opposite effect and enhances the association of TRPA1 and TRPV1 to inhibit TRPA1. T100-Mut contains the C-terminal sequence of Tmem100-3Q and mimicks the effect of full-length Tmem100-3Q, inhibiting TRPA1-mediated activity and pain in a TRPV1-dependent manner. T100-Mut is also effective in animal models of pain. |
| Synonyms | Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA-OH, T100-Mut, WKVRQRNKKVQQQESQTALVVNQRCLFA |
| Molecular Weight | 2451.8 Da |
| Target | Protein-protein interactions,Transient receptor potential (TRP) channels |
| Amino Acid Sequence | Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: Myristoyl group at N terminal |
| References |
Weng et al (2014) Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain. Neuron 85(4) 833 PMID: 25640077 Related data All cell penetrating peptides >All transient receptor potential (TRP) channel modulators >All protein-protein interaction modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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