| Product Name | TAT 2-4 |
|---|---|
| Description |
TAT 2-4 is a cell-penetrating peptide, a dimer of the protein transduction domain (47-58) of HIV-tat protein. The TAT peptide (GRKKRRQRRRPQ) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus and acts as a cell-penetrating peptide. The TAT 2-4 peptide sequence (YGRKKRRQRRRGYGRKKRRQRRRG) represents two back-to-back protein transduction (cell-penetrating) domains of TAT. Transactivator of transcription (TAT) protein is produced by HIV-1 and is involved in the induction of HIV-associated neurologic disorders. |
| Synonyms | Transactivator of transcription peptide (2-4) |
| Molecular Weight | 3215.78 Da |
| Target | Antivirals |
| Amino Acid Sequence | YGRKKRRQRRRGYGRKKRRQRRRG |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Lu et al(2011) HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One 6(9) e23915 PMID: 21912650Hargus and Thayer (2013) Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. 33(45) 17908 PMID: 24198379Zou et al (2017) Progress in Research and Application of HIV-1 TAT-Derived Cell-Penetrating Peptide. J Membr Biol. 250(2) 115 PMID: 27933338 Related areasAll cell penetrating peptides > |
| Supplier | Isca Biochemicals Limited |
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