| Product Name | TAT-ANK |
|---|---|
| Description |
TAT-ANK is a peptide derived from amino acid residues 179–191 of the G-protein coupled receptor kinase interacting protein-1 (GIT1) ankyrin domain, which are are crucial for GIT1 binding to the Notch transcription repressor RBP-J. In vitro, application of TAT-ANK significantly inhibits Delta-like 4 (Dll4) expression and Notch 1 activation in human umbilical vein endothelial cells (HUVECs) by competing with activated Notch1 binding to RBP-J, and in mouse models, TAT-ANK reduces tumour size through impairing tumour angiogenesis. |
| Synonyms | ANK peptide |
| Molecular Weight | 2946.45 Da |
| Target | Nuclear receptor modulators,Protein-protein interactions |
| Amino Acid Sequence | YGRKKRRQRRRQTLQAELLVVYGA |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Zhu et al (2022) A novel peptide inhibitor of Dll4-Notch1 signalling and its pro-angiogenic functions. Br J Pharmacol. 1-16 PMID: 34796471 Related areasAll cell penetrating peptides >All protein-protein interaction modulators >All cancer research areas > |
| Supplier | Isca Biochemicals Limited |
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