| Product Name | TAT-CBD3 |
|---|---|
| Description | TAT-CBD3 is the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2) conjugated to the cell penetrating motif of the HIV transduction domain protein TAT, which is a modulator of N-type voltage-gated calcium channels (CaV2.2). TAT-CBD3 functions as a CRMP2 - CaV2.2 interaction inhibitor and reduces CaV2.2 mediated currents, and also reduces T-type currents, which results in reduced nociceptor excitability, diminished neuropeptide release from sensory neurons and lower excitatory synaptic transmission. TAT-CBD3 can also reduce hypersensitive behaviour in chemical-induced inflammatory and neuropathic animal pain models. |
| Synonyms | N-type voltage-gated calcium channels, CRMP-2, CRMP2 - CaV2.2 interaction, CaV2.2, H-YGRKKRRQRRRARSRLAELRGVPRGL-OH, PP-140 , T-type currents, TAT-CBD3, YGRKKRRQRRRARSRLAELRGVPRGL, collapsin response mediator protein 2, nociceptor, pain |
| Molecular Weight | 3192.78 Da |
| Target | Protein-protein interactions,Calcium channels |
| Amino Acid Sequence | YGRKKRRQRRRARSRLAELRGVPRGL |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Brittain et al (2011) Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. Nature Med. 17(7) 822 PMID: 21642979Fischer et al (2014) Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion. Gene Ther. 21(1) 44 PMID: 24152582 Related areasAll cell penetrating peptides >All protein-protein interaction modulators >All calcium channel modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
