| Product Name | TAT-CBD3A6K |
|---|---|
| Description | TAT-CBD3A6K is an optimised variation of CBD3, the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2), which is a modulator of N-type voltage-gated calcium channels (CaV2.2), conjugated to the cell penetrating motif of the HIV transduction domain protein TAT. TAT-CBD3A6K binds with greater affinity to Ca2+ channels and is more stable and less prone to unfolding than the parent peptide. TAT-CBD3A6K is anti-nociceptive in a rodent model of AIDS therapy-induced peripheral neuropathy |
| Synonyms | CRMP-2), CaV2.2, H-YGRKKRRQRRRARSRLKELRGVPRGL-OH, N-type voltage-gated calcium channels, PP-150, TAT-CBD3A6K, YGRKKRRQRRRARSRLKELRGVPRGL, axonal collapsin response mediator protein 2, nociceptive |
| Molecular Weight | 3249.87 Da |
| Target | Protein-protein interactions,Calcium channels |
| Amino Acid Sequence | YGRKKRRQRRRARSRLKELRGVPRGL |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Piekarz et al (2012) CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy. Mol. Pain 8 54 PMID: 22828369 Related areas All cell penetrating peptides >All protein-protein interaction modulators >All calcium channel modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
