| Product Name | Tat-CIRP |
|---|---|
| Description |
Tat-CIRP is a peptide derived from the high affinity binding region of cold-inducible RNA binding protein (CIRP) which competitively binds to myeloid differentiation factor 2 (MD2) and blocks the MD2-CIRP interaction. MD2 is an essential accessory protein for Toll like receptor 4 (TLR4) activation and blocking the function of MD2 and TLR4 with Tat-CIRP is neuroprotective, reducing apoptosis and necroptosis in vitro. In vivo, Tat-CIRP is neuroprotective against ischemic and hemorrhagic stroke in mice and reduces brain infarct volume and preserves neurological function in rhesus monkeys 30 days after ischemic stroke. |
| Synonyms | Tat-cold inducible RNA binding protein |
| Molecular Weight | 2997.34 Da |
| Target | Protein-protein interactions,Toll like receptors |
| Amino Acid Sequence | YGRKKRRQRRRGRGFSRGGGDRGYGG |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Fang et al (2021) An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Sci Transl Med. 13(597) eabb6716 PMID: 34108252 Related areasAll cell penetrating peptides >All protein-protein interaction modulators >All toll like receptor modulators >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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