| Product Name | TAT-Gap19 |
|---|---|
| Description |
TAT-Gap19 is a connexin43 (Cx43) hemichannel blocker, with an IC50 of 7 μM and no significant affinity for gap junctions or Panx1 channels. TAT-Gap19 is derived from Gap19, a sequence present on the intracellular cytoplasmic loop domain of Cx43, linked to the HIV-derived TAT internalization sequence to promote membrane permeability, which also allows brain penetration. In mouse models of liver damage, TAT-Gap19 can protect against liver fibrosis accompanied by superoxide dismutase overactivation and reduces production of inflammatory proteins. |
| Synonyms | 1507930-54-2, TAT Gap19, TAT-Gap19, YGRKKRRQRRRKQIEIKKFK |
| Molecular Weight | 2703.28 Da |
| Target | Gap junction channels |
| Amino Acid Sequence | YGRKKRRQRRRKQIEIKKFK |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1507930-54-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID: 25374505Crespo et al (2018) TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 9(3) 817 PMID: 29534516Ramadan (2020) Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage. Front Pharmacol. 11 212 PMID: 32210810 Related areasAll cell penetrating peptides >All gap junction channel modulators >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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