| Product Name | Tat-NTS peptide |
|---|---|
| Description |
Tat-NTS peptide is a cell-penetrating peptide consisting of Tat fused to amino acid residues R228 to F237 of the repeat III domain of ANXA1, which functions as a unique nuclear translocation signal (NTS). Tat-NTS peptide specifically blocks the interaction of ANXA1 with importin β and consequently the nuclear translocation of ANXA1. Tat-NTS peptide inhibits the transcriptional activity of p53, decreases Bid expression, suppresses activation of the caspase-3 apoptosis pathway and improves survival of neurons subjected to oxygen-glucose deprivation in vitro. In a focal brain ischemia animal model, Tat-NTS peptide reduces neuronal apoptosis in the ischemic zone and effects a dramatic reduction of infarct volume and a parallel improvement in neurological function after reperfusion. |
| Synonyms | Tat-NTS |
| Molecular Weight | 2855.4 Da |
| Target | Nuclear receptor modulators,Protein-protein interactions |
| Amino Acid Sequence | YGRKKRRQRRRRSFPHLRRVF-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References | Li et al (2019) A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell Death Differ. 26(2) 260 PMID: 29769639Related areasAll cell penetrating peptides >All protein-protein modulators >All nuclear receptor modulators >All neuroscience categories > |
| Supplier | Isca Biochemicals Limited |
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