| Product Name | Tat-βsyn-degron |
|---|---|
| Description | Tat-βsyn-degron is a blood brain barrier and plasma membrane permeable α-synuclein knockdown peptide which can reduce the level of α-synuclein by proteasomal degradation. Tat-βsyn-degron decreases α-synuclein aggregates and microglial activation in an α-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing human A53T α-synuclein, and reduces α-synuclein levels and significantly decreases the neuronal damage and motor impairment in a mouse toxicity model of Parkinsons disease. |
| Synonyms | Tat-βsyn-degron peptide |
| Molecular Weight | 3146.71 Da |
| Target | Protein-protein interactions,Proteasome |
| Amino Acid Sequence | YGRKKRRQRRRRTKSGVYLVGRRRG |
| Form | Freeze fried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Jin et al (2021) Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson€™s disease models. Commun. Biol. 4 232 PMID: 33608634 Related areasAll cell penetrating peptides >All protein-protein interaction modulators >All proteasome modulators >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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