| Product Name | tatM2NX |
|---|---|
| Description |
tatM2NX is a peptide generated by fusing part of the C-terminus of transient receptor potential melastin 2 (TRPM2) channels, corresponding more than 90% with the Nudix domain (M2NX), with the tat inducer of HIV. tatM2NX is a TRPM2 antagonist which prevents ligand binding and TRPM2 activation, and inhibits over 90% of human TRPM2 channel currents at concentrations as low as 2 μM. tatM2NX is an antagonist with an IC50 of 396 nM and is neuroprotective in animal models of focal and global ischemia. |
| Synonyms | TP-010, TP010, YGRKKRRQRRRGSREPGEMLPRKLKRVLRQEFWV, tatM2NX |
| Molecular Weight | 4354.17 Da |
| Target | Transient receptor potential (TRP) channels |
| Amino Acid Sequence | YGRKKRRQRRRGSREPGEMLPRKLKRVLRQEFWV |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Shimizu et al (2016) Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. Exp Neurol. 283(Pt A) 151 PMID: 27317297Cruz-Torres et al (2020) Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX. Mol Pharmacol. 97(2) 102 PMID: 31772034 Related dataAll cell penetrating peptides >All transient receptor potential channel modulators >All neuroscience categories > |
| Supplier | Isca Biochemicals Limited |
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