| Product Name | TCID |
|---|---|
| Description | TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID exhibits >100-fold selectivity for UCH-L3 over UCH-L1. TCID can also diminish glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons. |
| Synonyms | 30675-13-9, TCID, UCH-L3, ubiquitin C-terminal hydrolase-L3 |
| Molecular Weight | 283.91 Da |
| Target | Deubiquitinating enzymes |
| Amino Acid Sequence | 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione |
| Form | Off white solid |
| Purity | >99% (HPLC) |
| Cas Number | 30675-13-9 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863 PMID: 23484054 Related areasAll small molecules >All deubiquitinating enzyme modulators > |
| Supplier | Isca Biochemicals Limited |
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