| Product Name | tcY-NH2 |
|---|---|
| Description | tcY-NH2 is a selective PAR4 antagonist peptide which can block platelet aggregation caused by thrombin, without affecting ADP mediated aggregation. tcY-NH-2 also blocks PAR4 activation of the ERK pathway and through this mechanism can mediate aortic vascular smooth muscle cell migration and proliferation in rat models. |
| Synonyms | (trans-Cinnamoyl)-YPGKF-NH2, trans-cinnamoyl-YPGKF-NH2 |
| Molecular Weight | 739.87 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | trans-Cinnamoyl-YPGKF-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 327177-34-4 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide |
| References |
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771Peng (2019) Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function. Front. Immunology 10 1311 PMID: 31275306PubChem Related data All peptides >All protease activated receptor modulators >All cardiovascular research categories > |
| Supplier | Isca Biochemicals Limited |
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