| Product Name | Tertiapin Q |
|---|---|
| Description |
Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels. |
| Synonyms | TPNQ, TPN(Q) |
| Molecular Weight | 2452 Da |
| Target | Potassium channels |
| Amino Acid Sequence | ALCNCNRIIIPHQCWKKCGKK-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 910044-56-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide |
| References |
Jin and Lu (1999) Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry 38 14286 PMID: 10572003Jin et al (1999) Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry 38 14294 PMID: 10572004Kanjhan et al (2005) Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. J Pharmacol Exp Ther. 314(3) 1353 PMID: 15947038 Related areas All peptides >All potassium channel modulators >All cardiovascular research areas >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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