| Product Name | TFLLR-NH2 |
|---|---|
| Description |
TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 μM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-β secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface. |
| Synonyms | PAR1-AP |
| Molecular Weight | 647.82 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | TFLLR-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 197794-83-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351Mihara et al (2013) Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem. 288(46) 32979 PMID: 24052258Jia et al (2015) Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncology Reports 33(6) 2681 PMID: 25846512 Related data All peptides >All protease activated receptors >All immunology research categories >All cardiovascular research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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