| Product Name | Thyroglobulin |
|---|---|
| Description | Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. Ultra Pure Human Thyroglobulin. Cellulose acetate electrophoresis shows one band only, indicating ?1 electrophoretic mobility. Polyacrylamide gradient gel electrophoresis shows a band, corresponding to a molecular weight of approx. 660 kDa. Under certain conditions the subunit band of thyroglobulin may also be observed at 330 kDa Immunological identity verified by Thyroglobulin RID Presence of IgG not discernable by Thyroglobulin RID Protein determination by the method of Lowry and OD (280nm,1cm, 0.1%): 1.04, which corresponds to 9.21mg/ml (dispensing volume). |
| Synonyms | TG, TGN, AITD3 |
| Molecular Weight | 660000 |
| Form | Purified protein, in 0.02M NH4HCO3, may contain traces of buffer salts |
| Purity | >98% by SDS-PAGE |
| Storage | -2°C (aliquot) |
| Notes | Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens. |
| Background | Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. |
| Supplier | ARP |
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