| Product Name | TIM3 Monoclonal Antibody |
|---|---|
| Description | TIM3,also known as HAVCR2,is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection . TIM3 is expressed by T-helper type 1 (Th1) cells,macrophage,monocyte,dendritic cells,CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity . TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa,the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3 . |
| Synonyms | CD366,FLJ14428,HAVcr 2,HAVCR2,KIM 3,T cell membrane protein 3,Tim 3,TIM3,TIM-3,TIMD 3,TIMD3 |
| Host | Mouse |
| Clone | 4C4G3 |
| Immunogen | Fusion Protein of TIM3 |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q8TDQ0 |
| Background | TIM3,also known as HAVCR2,is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection . TIM3 is expressed by T-helper type 1 (Th1) cells,macrophage,monocyte,dendritic cells,CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity . TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa,the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3 . |
| Supplier | Elabscience |
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