| Product Name | TIP 39 |
|---|---|
| Description |
TIP 39, or Tuberoinfundibular peptide of 39 residues, is a peptide that was first identified from bovine hypothalamus, which in humans is encoded by the PTH2 gene. TIP39 is related to parathyroid hormone and PTH-related protein and is a potent and selective agonist at parathyroid hormone 2 (PTH2) receptors. PTH2 receptors are highly expressed in the nervous system, and have roles in the modulation of pituitary function and in nociception. |
| Synonyms | Tuberoinfundibular neuropeptide, Tuberoinfundibular peptide of 39 residues |
| Molecular Weight | 4504.24 Da |
| Target | Parathyroid hormone receptors |
| Amino Acid Sequence | SLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP |
| Form | Freeze dried solid |
| Purity | >95% |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Usdin et al (1999) TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat. Neurosci 2 941 PMID: 10526330Della Penna et al (2003) Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor, Neuropharmacology 44(1) 141 https://doi.org/10.1016/S0028-3908(02)00335-0Weaver et al (2017) High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5, Biochemical Pharmacology 127 71 PMID: 28012961 Related areas All peptides >All parathyroid hormone receptor modulators >All endocrinology research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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